Synthesis, Molecular Docking Studies and Cytotoxic Screening of Novel 2-Substituted Benzimidazole Derivatives

Cancer is one of the most serious lifethreatening diseases for which there presently no cure. According to current World Health Organization (WHO) reports cancer responsible out every six deaths worldwide. Benzimidazole a heterocyclic, aromatic molecule that acts as biological scaffold with anticancer, antitumor, and antiproliferative activities, among other effects. benzimidazole oxazole are important pharmacophore in medicinal chemistry, due their widespread pharmacological activities. So, exploit anticancer potential we have selected these two our research work. order develop agents, it was considered interest synthesize some derivatives. Before synthesis molecule, Molecular docking done afterwards compound lowest dock score synthesis. Synthesized derivatives Characterized By Proton Nuclear Magnetic Resonance (1H NMR), Infra-Red (IR), And Mass Spectroscopy (MS) screen cytotoxic activity.